BIOGRAPHICAL SKETCH

Education

Institution and Location

Degree

Completion Date

Field of Study

University of Shanghai for Science and Technology, Shanghai, China

B.S.

06/1982

Engineering

University of Shanghai for Science and Technology, Shanghai, China

M.S.

06/1984

Engineering

University of Delaware, Newark, DE, USA

Ph.D.

05/1993

Electrical Engineering

University of Pittsburgh, Pittsburgh, PA, USA.

Postdoc

08/1994

Medical Imaging

Positions and Employment

1994 – 2002

Research Assistant Professor, Department of Radiology, College of Medicine, University of Pittsburgh, Pittsburgh, PA

2002 – 2009

Research Associate Professor, Department of Radiology, University of Pittsburgh, Pittsburgh, PA

2009 – 2011

Research Professor, Department of Radiology, University of Pittsburgh, Pittsburgh, PA

2011 – 2013

Professor of Radiology, Department of Radiology, University of Pittsburgh, Pittsburgh, PA

2013 – present

Professor, School of Electrical and Computer Engineering, Gallogly College of Engineering, University of Oklahoma, Norman, OK

Other Scientific and Honors Appointments

Fellow

American Institute for Medicine and Biological Engineering (AIMBE)

Since 2014

Oklahoma TSET Cancer Research Scholar

Peggy and Charles Stephenson Cancer Center, University of Oklahoma

Since 2014

Editor-in-Chief

Journal of X-ray Science and Technology

Since 2016

Gerald Tuma Presidential Professorship

University of Oklahoma

Since 2020

Funded Research Projects

  • Following are funded research projects that I served as a Principal Investigator (PI).

1.  P20 GM135009 – NIGMS/NIH                               02/15/2022 – 12/31/2026

Oklahoma Center of Medical Imaging for Translational Cancer Research

      The objective of this project is to establish a new biomedical imaging research center with appropriate infrastructure and research capacity along with a multidisciplinary mentoring team to support the promising research project leaders of junior investigators as they conduct the innovative translational cancer research projects using advanced medical imaging technology. The success of this COBRE will ultimately have a high research and clinical impact lead to a reduced cancer burden both for individual patients and society as a whole.

2.  R01 CA197150 – NCI/NIH                                    07/01/2015 – 06/30/2021

Increasing Cancer Detection Yield Using Breast MRI Screening Modality

      The objective of this project is to investigate the new quantitative image feature analysis based risk models to predict the risk of women harboring mammography-occult cancer and apply the prediction results to better identify the women who can benefit from breast MRI screening and thus increase the cancer detection yield of using breast MRI screening modality.

3.  R01 CA160205 – NCI/NIH                                   04/01/2012 – 03/31/2017

Mammographic Density and Tissue Asymmetry Based Breast Cancer Risk Stratification

      The objective of this project is to investigate whether bilateral mammographic density asymmetry highly associates with the risk of women developing breast cancer in the short-term and develop a new short-term breast cancer risk assessment model. The success of this project will ultimately help establish new personalized breast cancer prevention and screening programs.

4.  R01 CA077850 – NCI/NIH                                      09/15/1998 – 04/30/2013

Improving Breast Cancer Detection and Diagnosis with CAD

       This project has been renewed twice in 2003 and 2008, respectively. In the 3rd funding cycle (2008 – 2013), the project focused on developing a new multi-view based CAD scheme to detect breast lesions using full-field digital mammograms (FFDM) and a new fusion method to increase CAD cuing on subtle cancers without increasing false-positive cues. An observer performance study was conducted to assess whether these 2 new approaches in CAD can help improve radiologists’ performance in detecting breast cancers at an earlier stage.

5.  R01 CA101733 – NCI/NIH                                            09/01/2004 – 08/31/2010

Interactive CAD for Mammography

      The objective of this project is to develop a unique interactive computer-aided diagnosis (ICAD) system and evaluate whether and how an ICAD system may help improve radiologists’ confidence in using computer-prompted detection results and ultimately help to detect more subtle cancers at an earlier stage.

6.  R21 CA085241 – NCI/NIH                                              04/01/2001 – 03/31/2003

CAD for Earlier Detection of Breast Cancer

      The objective of this project is to develop a new CAD scheme that focuses on optimization of mammograms that had been interpreted as negative but the patients were subsequently found to have breast cancers on a later examination. We tested whether using this new CAD training method can help detect more subtle or early breast cancers.

7.  R01 CA079754 – NCI/NIH                                                07/01/1999 – 06/30/2004

Detection and Localization in Mammography

      The objective of this project is to assess the impact of using CAD schemes on radiologists. Reader performance studies are used to measure and compare radiologists’ accuracy in detecting and localizing breast cancers with and without CAD prompting.

8.  DAMD 17-98-1-8018 – DOD CDMRP                                07/01/1998 – 06/31/2001

Mammographic Interpretation Errors in a Prompted Environment

      The objective of this project is to assess the effect of CAD cueing on non-cued abnormalities in a soft-display environment. A multi-mode based multi-reader and multi-case (MRMC) observer performance study was used to simulate cueing conditions in a soft-display environment at different sensitivity and specificity levels. The study results can help us better understand of how to optimally use CAD in future clinical environment to better assist radiologists.

  • Following are funded research projects that I served as a Principal Investigator (PI) of subcontract.

9.  R01 CA115320 – NCI/NIH                                                    06/01/2006 – 05/31/2011

A Computer Aided Chromosome Imaging Technique for Cancer Diagnosis

      The purpose of this project is to develop a high-speed microscopic imaging scanning system to automatically identify diagnosable metaphase chromosomes and develop a comprehensive computer-aided detection and diagnosis scheme to help improve accuracy and efficiency of diagnosis of leukemia.

10.  R01 CA136700 – NCI/NIH                                                       08/01/2009 – 07/31/2012

Automated FISH Imaging and Analysis for Screening Cervical Cancer        

      The purpose of this project is to test the feasibility of developing an innovative multi-channel microscopic imaging scanning system and CAD schemes that aim to help clinicians more accurately and efficiently screening and detecting cervical cancer using FISH imaging technology.

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